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Declaration of Compliance
  Annual Declaration for Purposes of California Health & Safety Code, §§ 119400-119402.

To the best of its knowledge and based upon a good faith understanding of the applicable statutory requirements, Sigma-Tau Pharmaceuticals, Inc. declares that it is in compliance, in all material respects, with its Comprehensive Compliance Program and California Health and Safety Code §§ 119400-119402 as of July 1, 2006 and July 1, 2007.

To the best of its knowledge and based upon a good faith understanding of the applicable statutory requirements, Sigma-Tau is not aware of any violations as of July 1, 2006 and July 1, 2007 of its Comprehensive Compliance Program or of California Health and Safety Code §§ 119400-119402 relating to California medical or health professionals that have not been addressed and for which corrective action has not been taken.

By making this declaration, Sigma-Tau is not asserting that in all circumstances it can prevent individual employees from conduct that deviates from its policies, but that it has made a good faith effort to enforce its Comprehensive Compliance Program, prevent violations, and address any inappropriate conduct that may occur.

A copy of the Declaration, the Annual Re-Declaration, or Sigma-Tau’s Comprehensive Compliance Program may be obtained by calling 1-800-775-8581.